Animal Models of Dilated Cardiomyopathy for Translational Research

  title={Animal Models of Dilated Cardiomyopathy for Translational Research},
  author={Fabio A. Recchia and Vincenzo Lionetti},
  journal={Veterinary Research Communications},
Recchia, F.A. Lionetti, V., 2007. Animal models of dilated cardiomyopathy for translational research. Veterinary Research Communications, 31(Suppl. 1), 35–41AbstractAnimal models of cardiovascular disease have proved critically important for the discovery of pathophysiological mechanisms and for the advancement of diagnosis and therapy. They offer a number of advantages, principally the availability of adequate healthy controls and the absence of confounding factors such as marked differences… 
[Animal models of cardiovascular disease].
Translational Cardiovascular Medicine ( I ) Animal Models of Cardiovascular Disease
The use of animal models to study cardiovascular disease has made a substantial contribution to increasing the authors' understanding of disease pathogenesis, has led to the development of diagnostic techniques, and has made it possible to verify the effectiveness of different preventative and therapeutic approaches, whether pharmacological or interventional.
An Assessment of the Molecular Basis of Toxininduc ed Dilated Cardiomyopathy in an Avian Animal Model By
Findings suggest that the mitochondrial DNA variation and ACTC expression may be associated with DCM, a disease of the myocardium that causes morbidity and premature death in humans and other domestic animals including turkeys.
Calcineurin protects the heart in a murine model of dilated cardiomyopathy.
Large Mammalian Animal Models of Heart Disease
This review presents the commonly-used large animals—dog, sheep, pig, and non-human primates—while the less-used other large animals"—cows, horses—are excluded and attempts to introduce unique points for each species regarding its biological property, degrees of susceptibility to develop certain types of heart diseases, and methodology of induced conditions.
Animal Models of Heart Failure
In this chapter, animal models of HF are discussed with particular focus on similarities between the animal model and the failing human heart regarding myocardial function as well as molecular and subcellular mechanisms.
Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model
The feasibility of canines as a naturally occurring bidirectional disease model for DCM in both species is analyzed and a novel method using canine engineered stem cells to uncover unknown contributions of mistakes in DNA to the progression of DCM will be introduced along with its applications for human DCM disease modeling and treatment.
Small mammalian animal models of heart disease.
This review presents a guideline for the commonly used small animal models used in cardiac research as an effort to standardize the most relevant procedures and obtain translatable and reproducible results.
Animal models of myocardial infarction: Mainstay in clinical translation.
Vascular dysfunction in idiopathic dilated
Animal models closely resembling the marked vascular alterations found in patients with iDCM will be of paramount importance for further enhancing the authors' comprehension of disease progression and for testing new drugs and stem-cell or gene-based therapies.


Large animal models of congestive heart failure: A critical step in translating basic observations into clinical applications
  • W. YarbroughF. Spinale
  • Medicine, Biology
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
  • 2003
Large animal models of CHF are critical components in the effort to translate basic observations into beneficial clinical applications and may be used in conjunction with imaging modalities to elucidate the identification of cellular and extracellular alterations associated with LV failure.
Models of dilated cardiomyopathy in the mouse and the hamster.
This work will focus on small animal models of DCM, particularly those in the mouse, together with some comments on the autosomal-recessive cardiomyopathy of the hamster.
Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy
A working group to discuss the reasons for the failure to translate potential therapies for protecting the heart from ischemia and reperfusion concluded that cardioprotection in the setting of acute myocardial infarction, cardiac surgery, and cardiac arrest is at a crossroads.
Experimental models for the study of cardiovascular function and disease.
This article endeavours to identify some of these strengths and weaknesses and reveals the frequently encountered paradox that the greater the amount and reproducibility of data the further removed is the model from clinical reality.
Expression profiling of human idiopathic dilated cardiomyopathy.
Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition.
GH treatment alone improved LV dysfunction at 4 months of age in CM hamsters by increasing contractility and reducing wall stress but had few beneficial effects at 10 months in severe LV failure, which may relate to the progressive increase of LV fibrosis in the CM hamster.
Mechanisms of Increased Vascular Superoxide Production in an Experimental Model of Idiopathic Dilated Cardiomyopathy
Oxidative stress in CHF is mediated by NADPH oxidase and an uncoupled NOSIII secondary to an activation of the renin-angiotensin system leading to impaired NO downstream signaling.
The underlying cause of heart failure has prognostic value in patients with unexplained cardiomyopathy, and patients with peripartum cardaomyopathy appear to have a better prognosis than those with other forms of carduomyopathy.
Incidence, causes, and outcomes of dilated cardiomyopathy in children.
In children, DCM is a diverse disorder with outcomes that depend largely on cause, age, and heart failure status at presentation, and race, sex, and age affect the incidence of disease.
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy.
The underlying cause of heart failure has prognostic value in patients with unexplained cardiomyopathy and patients with peripartum cardiopathy appear to have a better prognosis than those with other forms of cardiomeopathy.