Animal Models of Calcific Aortic Valve Disease

  title={Animal Models of Calcific Aortic Valve Disease},
  author={Krista Sider and Mark C. Blaser and Craig A. Simmons},
  booktitle={International journal of inflammation},
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the… CONTINUE READING


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