Anillin Is a Scaffold Protein That Links RhoA, Actin, and Myosin during Cytokinesis

@article{Piekny2008AnillinIA,
  title={Anillin Is a Scaffold Protein That Links RhoA, Actin, and Myosin during Cytokinesis},
  author={Alisa J. Piekny and Michael Glotzer},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={30-36}
}
Cell division after mitosis is mediated by ingression of an actomyosin-based contractile ring. The active, GTP-bound form of the small GTPase RhoA is a key regulator of contractile-ring formation. RhoA concentrates at the equatorial cell cortex at the site of the nascent cleavage furrow. During cytokinesis, RhoA is activated by its RhoGEF, ECT2. Once activated, RhoA promotes nucleation, elongation, and sliding of actin filaments through the coordinated activation of both formin proteins and… CONTINUE READING
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