Anhedonia and major depression: The role of agomelatine

  title={Anhedonia and major depression: The role of agomelatine},
  author={Massimo Di Giannantonio and Giovanni Martinotti},
  journal={European Neuropsychopharmacology},
The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder
The unmet need in depression is to improve patient functioning and other patient-reported outcomes (e.g., quality of life), and antidepressant interventions capable of attenuating anhedonia as well as cognitive dysfunction in MDD may help in this regard.
Therapeutic Potential of Vortioxetine for Anhedonia-Like Symptoms in Depression: A Post Hoc Analysis of Data from a Clinical Trial Conducted in Japan
Vortioxetine may have therapeutic potential in patients with anhedonia-like symptoms of major depressive disorder, according to a post hoc analysis of an 8-week, randomized, double-blind, placebo-controlled, phase 3 study of this multimodal antidepressant.
Anhedonia w zaburzeniach depresyjnych
Agomelatine is an antidepressant with the best documented and proven efficacy in reducing the increased depressive anhedonia and the lowest potential to cause drug-inducedAnhedonia, which results in the enhancement of dopaminergic and noradrenergic transmission.
Anhedonia in depressed patients on treatment with selective serotonin reuptake inhibitor anti-depressant—A two-centered study in Malaysia
  • A. Yee, S. Chin, C. G. Ng
  • Psychology, Medicine
    International journal of psychiatry in clinical practice
  • 2015
Anhedonia often persists in depressed patients despite on SSRI anti-depressant treatment, and this study aims to compare the level of anhedonia between depressed patients on anti-Depressants and healthy subjects.
[Anhedonia in depression].
The Role of Agomelatine in the Treatment of Anxiety Disorders
The clinical efficacy and the relative good tolerability of agomelatine may be further investigated to widen the therapeutic spectrum of ADs.
Agomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression
Current evidences on the role of agomelatine in disorders other than major depression are elucidated to point out a possible efficacy of such drug in the treatment of bipolar depression, anxiety disorders, alcohol dependence, migraines etc.


Agomelatine Versus Venlafaxine XR in the Treatment of Anhedonia in Major Depressive Disorder: A Pilot Study
AGO showed significantly greater efficacy on anhedonia and similar antidepressant efficacy to the serotonin-norepinephrine reuptake inhibitor VLX in patients with major depressive disorder during an 8-week treatment period.
Anhedonia: a neglected symptom of psychopathology
  • P. Snaith
  • Psychology
    Psychological Medicine
  • 1993
It is possible that anhedonia may provide the key to a more exact delineation of depressive disorders in biological research and in clinical practice, which will depend upon a more precise, cross-nationally agreed definition of the concept and the means of its assessment.
Anhedonia and Substance-Related Symptoms in Detoxified Substance-Dependent Subjects: A Correlation Study
The composite instrument employed for assessing anhedonia and hedonic capability was found to be sensitive enough to detect such a dimension in the population considered, with the single scales significantly interrelated.
Is anhedonia a good measure of depression?
The results showed that, although depressed patients scored highly for anhedonia, this symptom was present in the majority of patients with diagnoses other than major depressive illness, and it may therefore be inappropriate to useAnhedonia as the basis for a diagnostic measure.
Anhedonia, suicide ideation and dexamethasone nonsuppression in depressed patients.
Agomelatine in the treatment of major depressive disorder: an 8-week, multicenter, randomized, placebo-controlled trial.
Agomelatine 25 mg/d was effective in the treatment of patients with moderate-to-severe MDD and was safe and well tolerated, although clinically notable aminotransferase elevations were observed transiently in the agomel atine 50mg/d group.
Physical anhedonia in Parkinson’s disease
Physical anhedonia appears to be a relatively frequent, although mild, affective disturbance of PD, independent from neurological, frontal, and depressive aspects, according to clinical, neuropsychological, and quantitative neuroradiological features.