Anhedonia and major depression: The role of agomelatine

@article{Giannantonio2012AnhedoniaAM,
  title={Anhedonia and major depression: The role of agomelatine},
  author={Massimo Di Giannantonio and Giovanni Martinotti},
  journal={European Neuropsychopharmacology},
  year={2012},
  volume={22},
  pages={S505-S510}
}
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54 Citations
Highly Influential Citations
1
Background Citations
12
Methods Citations
2
Results Citations
4

54 Citations

Citation Type

Citation Type

The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder
TLDR
The unmet need in depression is to improve patient functioning and other patient-reported outcomes (e.g., quality of life), and antidepressant interventions capable of attenuating anhedonia as well as cognitive dysfunction in MDD may help in this regard.
Therapeutic Potential of Vortioxetine for Anhedonia-Like Symptoms in Depression: A Post Hoc Analysis of Data from a Clinical Trial Conducted in Japan
TLDR
Vortioxetine may have therapeutic potential in patients with anhedonia-like symptoms of major depressive disorder, according to a post hoc analysis of an 8-week, randomized, double-blind, placebo-controlled, phase 3 study of this multimodal antidepressant.
Anhedonia in depressed patients on treatment with selective serotonin reuptake inhibitor anti-depressant—A two-centered study in Malaysia
  • A. Yee, S. Chin, C. G. Ng
  • Psychology, Medicine
    International journal of psychiatry in clinical practice
  • 2015
TLDR
Anhedonia often persists in depressed patients despite on SSRI anti-depressant treatment, and this study aims to compare the level of anhedonia between depressed patients on anti-Depressants and healthy subjects.
[Anhedonia in depression].
The Role of Agomelatine in the Treatment of Anxiety Disorders
TLDR
The clinical efficacy and the relative good tolerability of agomelatine may be further investigated to widen the therapeutic spectrum of ADs.
Comparative effectiveness of repeated ketamine infusions in treating anhedonia in bipolar and unipolar depression.
Agomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression
TLDR
Current evidences on the role of agomelatine in disorders other than major depression are elucidated to point out a possible efficacy of such drug in the treatment of bipolar depression, anxiety disorders, alcohol dependence, migraines etc.
Effects of levomilnacipran ER on noradrenergic symptoms, anxiety symptoms, and functional impairment in adults with major depressive disorder: Post hoc analysis of 5 clinical trials.
Efficacy and Safety of Agomelatine vs Paroxetine Hydrochloride in Chinese Han Patients with Major Depressive Disorder: A Multicentre, Double-Blind, Noninferiority, Randomized Controlled Trial
TLDR
Agomelatine showed equivalent antidepressant efficacy to paroxetine in treating MDD patients after 8 weeks of treatment with an acceptable safety.
Anhedonia predicts poor psychosocial functioning: Results from a large cohort of patients treated for major depressive disorder by general practitioners
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References

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Major depressive disorder, anhedonia, and agomelatine: An open-label study
Agomelatine Versus Venlafaxine XR in the Treatment of Anhedonia in Major Depressive Disorder: A Pilot Study
TLDR
AGO showed significantly greater efficacy on anhedonia and similar antidepressant efficacy to the serotonin-norepinephrine reuptake inhibitor VLX in patients with major depressive disorder during an 8-week treatment period.
Anhedonia: a neglected symptom of psychopathology.
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  • Psychology
    Psychological medicine
  • 1993
TLDR
It is possible that anhedonia may provide the key to a more exact delineation of depressive disorders in biological research and in clinical practice, which will depend upon a more precise, cross-nationally agreed definition of the concept and the means of its assessment.
Anhedonia and Substance-Related Symptoms in Detoxified Substance-Dependent Subjects: A Correlation Study
TLDR
The composite instrument employed for assessing anhedonia and hedonic capability was found to be sensitive enough to detect such a dimension in the population considered, with the single scales significantly interrelated.
Is anhedonia a good measure of depression?
TLDR
The results showed that, although depressed patients scored highly for anhedonia, this symptom was present in the majority of patients with diagnoses other than major depressive illness, and it may therefore be inappropriate to useAnhedonia as the basis for a diagnostic measure.
[Anhedonia in psychiatry: a review].
TLDR
The literature is reviewed and it is concluded that anhedonia appears to be a multi-morphological symptom and the are probably several types of anhedonian, which shows the necessity of developing more specific reliable evaluation instruments and of diversifying the approaches.
Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects
The assessment of anhedonia in clinical and non-clinical populations: further validation of the Snaith-Hamilton Pleasure Scale (SHAPS).
Anhedonia, suicide ideation and dexamethasone nonsuppression in depressed patients.
Agomelatine in the treatment of major depressive disorder: an 8-week, multicenter, randomized, placebo-controlled trial.
TLDR
Agomelatine 25 mg/d was effective in the treatment of patients with moderate-to-severe MDD and was safe and well tolerated, although clinically notable aminotransferase elevations were observed transiently in the agomel atine 50mg/d group.
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