Angucycline C5 glycosides: regio- and stereocontrolled synthesis and cytotoxicity.

@article{Mitra2013AngucyclineCG,
  title={Angucycline C5 glycosides: regio- and stereocontrolled synthesis and cytotoxicity.},
  author={Prithiba Mitra and Birendra Behera and Tapas Kumar Maiti and Dipakranjan Mal},
  journal={The Journal of organic chemistry},
  year={2013},
  volume={78 19},
  pages={
          9748-57
        }
}
This study discloses a general and convergent route for the regio- and stereospecific construction of the C5 glycosyl angucycline framework of mayamycin. C-Glycosidation, dearomatization, and Hauser annulation are the key steps. The synthetic analogues show cytotoxicity against different human cancer cell lines with IC50 values between 16.4 and 1.2 μM. 
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