Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua.

@article{Morgan1999AngiotensinogenTV,
  title={Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua.},
  author={Thomas W. Morgan and Catherine Craven and J. M. Lalouel and Ken Ward},
  journal={American journal of obstetrics and gynecology},
  year={1999},
  volume={180 1 Pt 1},
  pages={95-102}
}
OBJECTIVE The angiotensinogen Thr235 polymorphism associated with preeclampsia is tightly linked to a mutation in the angiotensinogen promoter A(-6), which may lead to elevated expression in decidual spiral arteries. We hypothesize that locally elevated angiotensin II levels play a role in failed physiologic change leading to preeclampsia. Our objective was to determine whether spiral artery morphologic characteristics were different in first-trimester decidual samples from women homozygous for… CONTINUE READING

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