Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels

@article{Patil2008AngiotensinergicNI,
  title={Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels},
  author={Jaspal Patil and Eva Heiniger and Thomas Schaffner and Oliver M{\"u}hlemann and Hans Imboden},
  journal={Regulatory Peptides},
  year={2008},
  volume={147},
  pages={82-87}
}

Figures from this paper

Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia

Angiotensinergic neurotransmission in the peripheral autonomic nervous system.

TLDR
Immunocytochemical and gene expression data suggest that neuronal Ang II acts as a neuromodulatory peptide and co-transmitter in the peripheral autonomic, and also sensory nervous system.

Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia

Angiotensinergic and noradrenergic neurons in the rat and human heart

Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes

TLDR
The human right atrium harbors an abundant angiotensinergic innervation and a novel potential source of atrial Ang II, and neuronal Ang II release from these fibers may modulate cardiac and circulatory reflexes independently from plasma and tissue Ang II sources.

[Autonomic angiotensinergic fibres in the human heart with an efferent sympathetic cophenotype].

Angiotensinergic Innervation of the Kidney: Present Knowledge and Its Significance

TLDR
The data suggest a new role of Ang II as a co-transmitter stimulating renal target cells or modulating nerve traffic from or to the kidney, and Neuronal Ang II is likely to be an independent source of intrarenal Ang II.

References

SHOWING 1-10 OF 29 REFERENCES

A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues.

TLDR
This study demonstrates the widespread codistribution of renin and angiotensinogen mRNAs in many tissues of both species, allowing for the possibility of local angiotsin production, however, tissue and species differences in these gene expressions also exist.

Upregulation of Immunoreactive Angiotensin II Release and Angiotensinogen mRNA Expression by High-Frequency Preganglionic Stimulation at the Canine Cardiac Sympathetic Ganglia

TLDR
The levels of endogenous immunoreactive angiotensin II, as determined by radioimmunoassay in the incubation medium of the stellate and inferior cervical ganglia, were increased after the high-frequency preganglionic stimulation of the isolated ganglia.

Production of Angiotensin II by Homogeneous Cultures of Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

TLDR
Production of angiotensin II (Ang II) in spontaneously hypertensive rats (SHR)-derived vascular smooth muscle cells (VSMC) has now been investigated and Reverse transcription-polymerase chain reaction analysis revealed that the abundance of mRNAs encoding angiotENSinogen, cathepsin D, and ang Elliotensin-converting enzyme was greater than expected.

Influence of the renin-angiotensin system on sympathetic neurotransmission in canine skeletal muscle in vivo

SummaryThe physiological importance of interactions between angiotensin II and sympathetic neurotransmission was studied in an in vivo model with constant flow blood perfused gracilis muscle in situ

Interactions between angiotensin peptides and the sympathetic nervous system mediating intestinal sodium and water absorption in the rat.

TLDR
Data demonstrate that AII-increased intestinal absorption is secondary to the release of norepinephrine from nerve endings in the jejunum and that A II inhibition of absorption is not mediated by the sympathetic nervous system.

Vascular angiotensin-converting enzyme expression regulates local angiotensin II.

TLDR
It is concluded that local ACE gene expression and ACE activity can influence the local rate of Ang II production and lead to an increase in the conversion of Ang I to Ang II.

Regional angiotensin II production in essential hypertension and renal artery stenosis.

TLDR
Although regional production of angiotensin I at tissue sites made a significant contribution to its level in the veins, little of this locally produced angiotENSin I reached the regional veins in the form of ang Elliotensin II, even in the kidney with artery stenosis, where the venous levels of locally producedAngiotens in I were particularly high.

Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence.

TLDR
Renin research is redirected to renal mechanisms that create the plasma renin level, to renal prorenin biosynthesis and its processing to renin, and to their regulated secretion, extracellular distribution, and possible binding to by target tissues.

Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding.

TLDR
Patients with heart failure support the concept of local angiotensin production in the heart by renin that is taken up from the circulation by membrane binding may be part of the uptake process.