AngiotensinII mediates cardiomyocyte hypertrophic growth pathways via MMP-dependent HB-EGF liberation

@article{Smith2004AngiotensinIIMC,
  title={AngiotensinII mediates cardiomyocyte hypertrophic growth pathways via MMP-dependent HB-EGF liberation},
  author={Nicola J. Smith and Ross D Hannan and Walter Glen Thomas and Rebecca A. Lew},
  journal={Letters in Peptide Science},
  year={2004},
  volume={10},
  pages={431-435}
}
Pathological cardiac stimulation by angiotensinII (AngII) can cause left ventricular hypertrophy, a major independent risk factor for heart attack and death. We have previously reported that AngII exerts its hypertrophic effects by usurping the epidermal growth factor (EGF) signalling pathway via metalloprotease-dependent transactivation. However, the EGF… CONTINUE READING