Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin.

@article{Scheuer1993AngiotensinT2,
  title={Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin.},
  author={Deborah A. Scheuer and Mark H. Perrone},
  journal={The American journal of physiology},
  year={1993},
  volume={264 5 Pt 2},
  pages={R917-23}
}
Angiotensin (ANG) can produce a biphasic arterial pressure response, i.e., an increase followed by a decrease. Because ANG type 1 (AT1) receptors mediate the pressor response to ANG, we hypothesized that the opposing depressor action is mediated by the ANG type 2 (AT2) receptors. In thiobutabarbital (Inactin)-anesthetized rats bolus injections of angiotensin III (ANG III; 100, 300, and 1,000 ng/kg iv) produced peak increases in MAP at 20 s of 13.4 +/- 1.4, 20.1 +/- 2, and 27.5 +/- 2.8 mmHg and… CONTINUE READING