Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats.

@article{Rehman2012AngiotensinT2,
  title={Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats.},
  author={Asia Rehman and Avshalom Leibowitz and Naoki Yamamoto and Yohann Rautureau and Pierre Paradis and Ernesto L Schiffrin},
  journal={Hypertension},
  year={2012},
  volume={59 2},
  pages={291-9}
}
-Angiotensin type 2 receptor-mediated effects of angiotensin II appear to counteract many of the effects mediated via the angiotensin type 1 receptor. Compound 21 (C21), a selective angiotensin type 2 receptor agonist, has demonstrated beneficial effects on cardiac function after myocardial infarction in rodents. We hypothesized that C21 alone or in combination with an angiotensin type 1 receptor antagonist would blunt the development of hypertension and vascular damage in stroke-prone… CONTINUE READING