Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion.

@article{Wu2010AngiotensinRT,
  title={Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion.},
  author={Xiao-feng Wu and Tetsuro Kihara and Haruyuki Hongo and Akinori Akaike and Tetsuhiro Niidome and Hikaru Sugimoto},
  journal={British journal of pharmacology},
  year={2010},
  volume={161 1},
  pages={33-50}
}
BACKGROUND AND PURPOSE Several clinical trials and in vivo animal experiments have suggested that blockade of angiotensin receptor type 1 (AT(1)) improves ischaemic outcomes. However, the mechanism(s) underlying these effects has not been elucidated. Here, we have investigated the protective effects of pretreatment with AT(1) receptor antagonists, losartan or telmisartan, against ischaemic insult to neurons in vitro. EXPERIMENTAL APPROACH Primary rat neuron-astrocyte co-cultures and astrocyte… CONTINUE READING