Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue.

@article{Lee2008AngiotensinRB,
  title={Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue.},
  author={Mi Hwa Lee and Hye Kyoung Song and Gang Jee Ko and Young Sun Kang and Sang Youb Han and Kum Hyun Han and Hyoung Kyu Kim and Jee Young Han and Dae Ryong Cha},
  journal={Kidney international},
  year={2008},
  volume={74 7},
  pages={890-900}
}
Adipose tissue is recognized as a pivotal organ in the development of insulin resistance. This study seeks to determine the effect of angiotensin receptor blockade (ARB) on insulin resistance of adipocytes in culture and in a rat model of type 2 diabetes. Treatment of Otsuka Long-Evans Tokushima Fatty rats with the ARB L158809 for six months significantly lowered fasting plasma glucose, cholesterol and triglyceride levels but led to higher plasma adiponectin levels. Insulin resistance, measured… CONTINUE READING