Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.

@article{Matsusaka2010AngiotensinRB,
  title={Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.},
  author={Taiji Matsusaka and Takako Asano and Fumio Niimura and Masaru Kinomura and Akihiro Shimizu and Ayumi Shintani and Ira Pastan and Agnes B. Fogo and Iekuni Ichikawa},
  journal={Hypertension},
  year={2010},
  volume={55 4},
  pages={967-73}
}
In the present study, we tested the hypothesis that the renoprotective effect of an angiotensin receptor blocker depends on the angiotensin II type 1 (AT(1)) receptor on podocytes. For this purpose, we generated podocyte-specific knockout mice for the AT(1) gene (Agtr1a) and crossed with NEP25, in which selective podocyte injury can be induced by immunotoxin, anti-Tac(Fv)-PE38. Four weeks after the addition of anti-Tac(Fv)-PE38, urinary albumin:creatinine ratio was not attenuated in Agtr1a… CONTINUE READING

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