Angiotensin metabolites can stimulate receptors of the Mas-related genes family

  title={Angiotensin metabolites can stimulate receptors of the Mas-related genes family},
  author={Florian Gembardt and Sonja Grajewski and Martin Vahl and Heinz-Peter Schultheiss and T Walther},
  journal={Molecular and Cellular Biochemistry},
The Mas protooncogene encodes a G protein-coupled receptor, we identified, also by using the specific angiotensin-(1-7) antagonist A-779, to be associated with intracellular signaling of the angiotensin (Ang) II metabolite Ang-(1-7). Recently, Mas-related genes (Mrg) have been identified coding for the Mrg-receptor family. All family members share high sequence homology to Mas. Most of them are orphan receptors. To proof whether structure similarities of the Mrg receptors with Mas turn them… CONTINUE READING


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