Angiotensin-induced myocardial necrosis and renal failure in the rabbit: distribution of lesions and severity in relation to plasma angiotensin II concentration and arterial pressure.

Abstract

Angiotensin II was infused into conscious rabbits at various doses from 0.001 to 0.5 microgram . kg-1 . min-1 for 24 h, and caused multifocal myocardial necrosis, renal tubular necrosis and acute renal failure. The myocardial necroses were found principally in the left ventricle; only at the highest doses of angiotensin II were right ventricular lesions… (More)

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@article{Kremer1981AngiotensininducedMN, title={Angiotensin-induced myocardial necrosis and renal failure in the rabbit: distribution of lesions and severity in relation to plasma angiotensin II concentration and arterial pressure.}, author={Daniel Kremer and George B. M. Lindop and W. C. Brown and John Morton and Jack Robertson}, journal={Cardiovascular research}, year={1981}, volume={15 1}, pages={43-6} }