Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.

@article{Schut2004AngiotensinCE,
  title={Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.},
  author={Anna F. C. Schut and Gys{\`e}le S. Bleumink and Bruno C. Stricker and Albert Hofman and Jacqueline C. M. Witteman and Huibert A. P. Pols and Jaap Willem Deckers and J. T. Deinum and Cornelia M van Duijn},
  journal={European heart journal},
  year={2004},
  volume={25 23},
  pages={2143-8}
}
AIMS Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. METHODS AND RESULTS We investigated 4264 normotensive and 2174 hypertensive participants of the Rotterdam Study, a… CONTINUE READING

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