Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.

@article{Yanagisawa1987AngiotensinconvertingEI,
  title={Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.},
  author={Hiroaki Yanagisawa and Sayaka Ishihara and Akira L. Ando and Takuro Kanazaki and Shigehiko Miyamoto and Hiroyuki Koike and Yasuteru Iijima and Keiichiro Oizumi and Yoshihiro Matsushita and Tsunetake Hata},
  journal={Journal of medicinal chemistry},
  year={1987},
  volume={30 11},
  pages={
          1984-91
        }
}
alpha-[6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxoperhydro -1,4-thiazepin-4-yl]acetic acids (monoester monoacids) and their dicarboxylic acids having the hydrophobic substituents at the 2- or 3-position of the thiazepinone ring were prepared and assayed for angiotensin-converting enzyme (ACE) inhibitory activity. The dicarboxylic acids having the pseudoequatorial amino groups at the 6-position and the pseudoequatorial hydrophobic substituents at the 2- or 3-position of the chair… CONTINUE READING
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