Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary angioedema: a comparison study of attack severity.

Abstract

Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.

DOI: 10.2169/internalmedicine.54.4181

Cite this paper

@article{Javaud2015AngiotensinconvertingEI, title={Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary angioedema: a comparison study of attack severity.}, author={Nicolas Javaud and St{\'e}phane Charpentier and Fr{\'e}d{\'e}ric Lapostolle and Hakim Lekouara and Marouane Boubaya and Gilles Lenoir and A Mekinian and Fr{\'e}d{\'e}ric Adnet and Olivier Fain}, journal={Internal medicine}, year={2015}, volume={54 20}, pages={2583-8} }