Angiotensin-converting enzyme inhibition restores hepatocyte growth factor production in patients with congestive heart failure.

@article{Yasuda1999AngiotensinconvertingEI,
  title={Angiotensin-converting enzyme inhibition restores hepatocyte growth factor production in patients with congestive heart failure.},
  author={Satoshi Yasuda and Yukie Goto and Hitoshi Sumida and Teruo Noguchi and Takao Baba and Shunichi Miyazaki and Hiroshi Nonogi},
  journal={Hypertension},
  year={1999},
  volume={33 6},
  pages={1374-8}
}
Endothelium-dependent vasodilation is impaired in patients with congestive heart failure. For vascular endothelium, hepatocyte growth factor (HGF) is one of the most potent and specific growth factors, which acts protectively against endothelial dysfunction. HGF production is downregulated by angiotensin II (Ang II) in vitro. We hypothesized that HGF production is impaired as the result of increased Ang II in patients with congestive heart failure, and that if so, the impaired production should… CONTINUE READING

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A critical look at cardiovascular translational research.

The American journal of physiology • 1999
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