Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism.

@article{LopezReal2005AngiotensinconvertingEI,
  title={Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism.},
  author={Ana Lopez-Real and Pablo Rey and Ram{\'o}n Soto-Otero and Estefan{\'i}a M{\'e}ndez-{\'A}lvarez and Jose L Labandeira-Garcia},
  journal={Journal of neuroscience research},
  year={2005},
  volume={81 6},
  pages={865-73}
}
It is now established that the brain possesses a local renin-angiotensin system and that angiotensin II exerts multiple actions in the nervous system, including regulation of striatal dopamine release. Furthermore, angiotensin activates NADPH-dependent oxidases, which are a major source of superoxide, and angiotensin-converting enzyme inhibitors, commonly used in the treatment of hypertension and chronic heart failure, have shown antioxidant properties in several tissues. Oxidative stress is a… CONTINUE READING
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