Angiotensin converting enzyme inhibition improves glomerular size-selectivity in IgA nephropathy.

  title={Angiotensin converting enzyme inhibition improves glomerular size-selectivity in IgA nephropathy.},
  author={Andrea Remuzzi and E Perticucci and Piero Ruggenenti and Lidia Mosconi and Monica Limonta and Giuseppe Remuzzi},
  journal={Kidney international},
  volume={39 6},
Clearances of uncharged dextrans of broad size distribution were used to evaluate the effects of a 30 day course of enalapril on glomerular barrier function in 10 patients with IgA nephropathy and proteinuria (from 1.4 to 5.6 g/day). Dextran clearance experiments were repeated three times: before enalapril therapy, after 30 days of enalapril and again 30 days after enalapril withdrawal. GFR, but not RPF, was significantly reduced by enalapril (basal 38.3 +/- 11.9, enalapril 30.2 +/- 12.6 ml/min… CONTINUE READING

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