Angiotensin-converting enzyme inhibition and physical training in heart failure.

  title={Angiotensin-converting enzyme inhibition and physical training in heart failure.},
  author={Theo Meyer and Barbara Casadei and Andrew J. S. Coats and Patrick Davey and Stergios Adamopoulos and A Radaelli and James Conway},
  journal={Journal of internal medicine},
  volume={230 5},
A total of 12 patients (mean age +/- SEM 63 +/- 2.6 years) with moderate to severe heart failure (ejection fraction = 23 +/- 3.2%) were included in a placebo-controlled crossover trial. Patients were randomly allocated to 4 periods of 6 weeks each: placebo, placebo and physical training, lisinopril 10 mg daily, and lisinopril and physical training. The exercise time increased from 13.6 +/- 0.9 min with placebo to 15 +/- 1 min with training alone, and to 16.1 +/- 0.7 min with lisinopril and… CONTINUE READING

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