Corpus ID: 42852464

Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.

@article{Delles2002AngiotensinCE,
  title={Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.},
  author={Christian Delles and Markus P Schneider and Stefan John and Michael Gekle and Roland E Schmieder},
  journal={American journal of hypertension},
  year={2002},
  volume={15 7 Pt 1},
  pages={
          590-3
        }
}
  • Christian Delles, Markus P Schneider, +2 authors Roland E Schmieder
  • Published 2002
  • Medicine
  • American journal of hypertension
  • BACKGROUND Asymmetrical N(G), N(G)-dimethylarginine (ADMA) is associated with impaired endothelium-dependent vasodilation in humans. METHODS Twenty young, male, mildly hypertensive subjects were included in a randomized, double-blind, fourfold cross-over study with placebo, enalapril (20 mg/day), eprosartan (600 mg/day), or a combination of both drugs (10 and 300 mg/day, respectively) each over 1 week, followed by a 2-week wash-out phase. After each treatment phase, ADMA concentration was… CONTINUE READING

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