• DOI:10.1007/s00394-014-0802-0
• Corpus ID: 12217105

Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children

@article{Mrginean2014AngiotensinconvertingEG,
  title={Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children},
  author={Cristina Oana Mărginean and Claudia Bănescu and Carmen Duicu and Septimiu Voidăzan and Claudiu Mǎrginean},
  journal={European Journal of Nutrition},
  year={2014},
  volume={54},
  pages={1245-1254}
}

• C. Mărginean, C. Bănescu, +2 authors C. Mǎrginean
• Published 1 December 2015
• Medicine, Biology
• European Journal of Nutrition

Purpose The aim of this study was to establish the role of angiotensin-converting enzyme gene insertion/deletion (ACE I/D) polymorphism in determining obesity or undernutrition in a child population in Romania.Methods We assessed 293 consecutively hospitalized patients in a tertiary emergency pediatric hospital. The patients were divided, according to body mass index (BMI), into three groups: group I, the control group consisting of 126 children, group II patients with undernutrition (85 patients) and group III patients with obesity (82 patients). ACE I/D polymorphisms were performed in all three patient groups, as well as the measuring of anthropometric parameters [middle upper arm circumference (MUAC), tricipital skinfold thickness (TST)]. All patients also underwent paraclinical evaluations (protein and albumin). The cutoffs criteria for moderate undernutrition were: BMI between −2.0 SD and −3.0 SD, severe undernutrition: BMI <−3.0 SD, moderate obesity: BMI between +2.0 SD and +3.0 SD and severe obesity: BMI >+3.0 SD.ResultsWe observed that DD genotype (64.7 %) was prevalent in the moderate undernutrition group, while ID (35.3 %) and II genotypes were higher in the subgroup of severe undernutrition, with significant correlations in DD and ID genotype groups between BMI and MUAC, protein and albumin (p < 0.0001). In the obese group, we observed significant correlations in DD genotype, between BMI and MUAC (p = 0.0014) and TST, and for II genotype, between BMI and TST (p = 0.0071). II genotype was associated with severe obesity, while D allele carriers were associated with moderate undernutrition and moderate obesity.ConclusionBMI, MUAC, TST and serum protein levels are correlated with D allele carriers of ACE genes in children with moderate undernutrition and moderate obesity, whereas II genotype is an unfavorable prognostic factor corresponding to severe obesity and severe undernutrition.