Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children

  title={Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children},
  author={Cristina Oana Mărginean and Claudia Bănescu and Carmen Duicu and Septimiu Voidăzan and Claudiu Mǎrginean},
  journal={European Journal of Nutrition},
Purpose The aim of this study was to establish the role of angiotensin-converting enzyme gene insertion/deletion (ACE I/D) polymorphism in determining obesity or undernutrition in a child population in Romania.Methods We assessed 293 consecutively hospitalized patients in a tertiary emergency pediatric hospital. The patients were divided, according to body mass index (BMI), into three groups: group I, the control group consisting of 126 children, group II patients with undernutrition (85… 
Angiotensin-Converting Enzyme Ins/Del Polymorphism and Body Composition: The Intermediary Role of Hydration Status
The relationship between the ACE Ins/Del polymorphism and body composition is confirmed and a role for hydration status in modulating this relationship is suggested to disentangle the genetic role of ACE on hydration homeostasis.
MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity
The study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
Early Inflammatory Status Related to Pediatric Obesity
It is proved that leukocyte, lymphocyte, erythrocyte, platelet, and platelet levels are significantly higher in overweight/obese children, emphasizing the inflammatory status related to this condition.
The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis
Even though the aim of the study was to establish correlations between the presence of Helicobacter pylori proved histologically and NLR in children, the mean NLR values were higher HP-positive patients, and significant differences in term of NLR was not identified.
Assessment of the relationship between ACE I/D gene polymorphism and renal allograft survival
Interestingly, the ACE D allele and DD genotype were associated with renal allograft survival after renal transplantation in the Asian population, however, more studies should be performed to confirm this association.
Obesity‐related genetic polymorphisms and adiposity indices in a young Italian population
To clarify the role of genetics in multifactorial diseases remains a difficult goal, even for the most investigated polymorphisms and in controlled populations, and further studies on epistasis and gene–gene interaction will help to elucidate this complex scenario.
The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article)
In mothers with excessive gestational weight gain, a significant association is found between the variant genotype of PNPLA3 rs738409 polymorphism and neonatal PI noticing a decrease of this index in case of newborns from mothers carrying the variantgenotype.
Fascin-1 and its role as a serological marker in prostate cancer: a prospective case–control study
Although serum values of FSCN1 were dissimilar in the two cohorts of patients, the difference was not statistically significant and further studies are required to evaluate a possible diagnostic role of F SCN1 in prostate cancer.


Insertion/deletion polymorphism of angiotensin-1 converting enzyme is associated with metabolic syndrome in Hungarian adults
The aim of our study was to evaluate whether any association exists between metabolic syndrome (MS) and ACE I/D and AGT M235T gene polymorphisms in Hungarians as an example of European Caucasian
Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech adult population
Based on the findings, the ID ACE polymorphism could represent a gene modulator of carbohydrate intake in morbidly obese Czech population; the strong significant effect of DD genotype was observed in the phenotypes of extreme obesity with the highest carbohydrate intake.
Effects of interaction between angiotensin I-converting enzyme polymorphisms and lifestyle on adiposity in adolescent Greeks.
There is a strong association (p = 0.001) between subcutaneous fat and the ACE insertion/deletion (I/D) polymorphism in females, possession of genotypes containing the D allele being associated with increased fat thickness, and this association is strongest in females who participate in no extra exercise.
Angiotensin-converting Enzyme Gene Polymorphism and Risk of Glucose Intolerance in Korean Men
Findings provide an evidence for the interaction of fetal ACE genotype and intrauterine environmental factor in predisposition to type 2 diabetes mellitus in offspring born during the war-induced famine.
ACE I/D genotype, adiposity, and blood pressure in children
ACE D- carriers are heavier than ACE II children; however, BP did not differ by ACE I/D genotype but was adversely influenced in the overfat D-carriers, and further studies are warranted to investigate the genetics of fatness and BP phenotypes in children.
Genetic Variation in the ReninAngiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study
The relationship of overweight, obesity, and body fat distribution to three common polymorphisms of the reninangiotensin system is investigated in adult men who attended the 19941995 follow-up examination of the Olivetti Prospective Heart Study.
A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity
  • S. Mao, Songming Huang
  • Medicine, Biology
    Journal of the renin-angiotensin-aldosterone system : JRAAS
  • 2015
DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations and Africans, particularly in Africans.
Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS).