Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.

@article{Zou2007AngiotensinconvertingEC,
  title={Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.},
  author={Kun Zou and Haruyasu Yamaguchi and Hiroyasu Akatsu and Takaaki Sakamoto and Mihee Ko and Kazushige Mizoguchi and Jian-Sheng Gong and Wenxin Yu and Takayuki Yamamoto and Katsuko Kosaka and Katsuhiko Yanagisawa and Makoto Michikawa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 32},
  pages={
          8628-35
        }
}
The abnormal deposition of the amyloid beta-protein (Abeta) in the brain appears crucial to the pathogenesis of Alzheimer's disease (AD). Recent studies have suggested that highly amyloidogenic Abeta(1-42) is a cause of neuronal damage leading to AD pathogenesis and that monomeric Abeta(1-40) has less neurotoxicity than Abeta(1-42). We found that mouse and human brain homogenates exhibit an enzyme activity converting Abeta(1-42) to Abeta(1-40) and that the major part of this converting activity… CONTINUE READING

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