Angiotensin-converting enzyme and genetics at high altitude.

  title={Angiotensin-converting enzyme and genetics at high altitude.},
  author={David Richard Woods and Hugh E. Montgomery},
  journal={High altitude medicine & biology},
  volume={2 2},
As part of the renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE) plays a key role in circulatory homeostasis. ACE degrades vasodilator kinins and generates angiotensin II. A polymorphism in intron 16 of the human ACE gene has been identified in which the presence (insertion, I allele) rather than the absence (deletion, D allele) of a 287 bp fragment is associated with lower serum and tissue ACE activity. The I allele has been associated with some aspects of endurance… CONTINUE READING


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