Angiotensin-converting enzyme 2 protects from severe acute lung failure

  title={Angiotensin-converting enzyme 2 protects from severe acute lung failure},
  author={Yumiko Imai and Keiji Kuba and Shuan Rao and Yi Huan and Feng Guo and Bin Guan and Peng Yang and Renu Sarao and Teiji Wada and Howard Leong-Poi and Michael A. Crackower and Akiyoshi Fukamizu and Chi-Chung Hui and Lutz Hein and Stefan Uhlig and Arthur S Slutsky and Chengyu Jiang and Josef M. Penninger},
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a devastating clinical syndrome with a high mortality rate (30–60%) (refs 1–3). Predisposing factors for ARDS are diverse and include sepsis, aspiration, pneumonias and infections with the severe acute respiratory syndrome (SARS) coronavirus. At present, there are no effective drugs for improving the clinical outcome of ARDS. Angiotensin-converting enzyme (ACE) and ACE2 are homologues with different key… CONTINUE READING
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