Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury

  title={Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury},
  author={Gloria Juliana Rey-Parra and Arul Vadivel and Lavinia Coltan and Adam Hall and Farah Eaton and Manfred Schuster and Hans Loibner and Josef M. Penninger and Zamaneh Kassiri and Gavin Yadram Oudit and Bernard Th{\'e}baud},
  journal={Journal of Molecular Medicine},
Despite substantial progress, mortality and morbidity of the acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI), remain unacceptably high. There is no effective treatment for ARDS/ALI. The renin–angiotensin system (RAS) through Angiotensin-converting enzyme (ACE)-generated Angiotensin II contributes to lung injury. ACE2, a recently discovered ACE homologue, acts as a negative regulator of the RAS and counterbalances the function of ACE. We hypothesized that… CONTINUE READING
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