Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.

@article{Kloet2016AngiotensinTR,
  title={Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.},
  author={Annette D de Kloet and Soledad Pitra and Lei Wang and Helmut Hiller and David J. Pioquinto and Justin A. Smith and Colin Sumners and Javier E Stern and Eric G. Krause},
  journal={Endocrinology},
  year={2016},
  volume={157 8},
  pages={3167-80}
}
It is known that angiotensin-II acts at its type-1 receptor to stimulate vasopressin (AVP) secretion, which may contribute to angiotensin-II-induced hypertension. Less well known is the impact of angiotensin type-2 receptor (AT2R) activation on these processes. Studies conducted in a transgenic AT2R enhanced green fluorescent protein reporter mouse revealed that although AT2R are not themselves localized to AVP neurons within the paraventricular nucleus of the hypothalamus (PVN), they are… CONTINUE READING
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