Angiotensin Receptor–Neprilysin Inhibition

  title={Angiotensin Receptor–Neprilysin Inhibition},
  author={Ofer Havakuk and Uri Elkayam},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  pages={356 - 364}
  • O. HavakukU. Elkayam
  • Published 1 July 2017
  • Biology
  • Journal of Cardiovascular Pharmacology and Therapeutics
The novel combination sacubitril/valsartan represents a new therapeutic approach in the management of heart failure. With the simultaneous blockage of the enzyme neprilysin (by sacubitril) and angiotensin II receptors (by valsartan), this combination reduces the degradation of natriuretic peptides and other counterregulatory peptide systems while avoiding the deleterious effect of angiotensin II receptors activation and thereby encompasses a beneficial impact of 2 important neurohormonal… 

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