Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology.

@article{Kehoe2017AngiotensinIIIII,
  title={Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology.},
  author={Patrick G Kehoe and Elliott Hibbs and Laura E. Palmer and J Scott Miners},
  journal={Journal of Alzheimer's disease : JAD},
  year={2017},
  volume={58 1},
  pages={
          203-214
        }
}
Hyperactivity of the renin-angiotensin system (RAS) is associated with the pathogenesis of Alzheimer's disease (AD) believed to be mediated by angiotensin-II (Ang-II) activation of the angiotensin type 1 receptor (AT1R). We previously showed that angiotensin-converting enzyme-1 (ACE-1) activity, the rate-limiting enzyme in the production of Ang-II, is increased in human postmortem brain tissue in AD. Angiotensin-III (Ang-III) activates the AT1R and angiotensin type-2 receptor (AT2R), but its… CONTINUE READING

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