Angiotensin III activates nuclear transcription factor-kappaB in cultured mesangial cells mainly via AT(2) receptors: studies with AT(1) receptor-knockout mice.

@article{Lorenzo2002AngiotensinIA,
  title={Angiotensin III activates nuclear transcription factor-kappaB in cultured mesangial cells mainly via AT(2) receptors: studies with AT(1) receptor-knockout mice.},
  author={{\'O} Lorenzo and Marta Ruiz-Ortega and Yusuke Suzuki and M{\'o}nica Rup{\'e}rez and Vanesa Esteban and Takeshi Sugaya and Jes{\'u}s Egido},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 5},
  pages={1162-71}
}
Nuclear factor-kappaB (NF-kappaB) regulates many genes involved in renal pathophysiologic processes. It was previously demonstrated that angiotensin II (AngII) and its amino-terminal degradation product AngIII activate NF-kappaB in mesangial cells. However, which are the Ang receptor subtypes involved in the NF-kappaB pathway and whether these Ang peptides act through the same or different receptors in mesangial cells have not been evaluated. Under the culture conditions used, quiescent rat… CONTINUE READING
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