Angiotensin II type I antagonist on oxidative stress and heat shock protein 70 (HSP 70) expression in obstructive nephropathy.

@article{Manucha2005AngiotensinIT,
  title={Angiotensin II type I antagonist on oxidative stress and heat shock protein 70 (HSP 70) expression in obstructive nephropathy.},
  author={Walter A. F. Manucha and Liliana Carmen Carrizo and Celeste M Ruete and Henrik Molina and Patricia Vall{\'e}s},
  journal={Cellular and molecular biology},
  year={2005},
  volume={51 6},
  pages={547-55}
}
Angiotensin II, a profibrotic cytokine, plays a main role in the initiation of renal fibrogenesis at a very early stage leading to a progressive loss of renal function in unilateral ureteral obstruction (UUO). We studied the involvement of AT1 angiotensin II receptor in the physiopathology of tubulointerstitial fibrosis in UUO, focusing in the regulation of the oxidative stress state and in the HSP 70 expression, in renal tissue. UUO or control sham operation was perform to Wistar Kyoto rats… CONTINUE READING

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