Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.

@article{Benndorf2003AngiotensinIT,
  title={Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.},
  author={Ralf A. Benndorf and Rainer H. Boeger and S{\"u}leyman Erg{\"u}n and Anna Steenpass and Thomas Wieland},
  journal={Circulation research},
  year={2003},
  volume={93 5},
  pages={438-47}
}
Endothelial cell migration and tube formation in response to vascular endothelial growth factor (VEGF) play an important role in the process of angiogenesis. Recent data indicate that angiotensin type 2 (AT2) receptor stimulation is antiangiogenic. Therefore, we studied the effect of angiotensin II (Ang II) on VEGF-induced migration and in vitro tube formation of human endothelial cells. Ang II inhibited VEGF-induced migration of EA.hy926 cells, human coronary artery (HCA) and human dermal… CONTINUE READING
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