Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia.

  title={Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia.},
  author={Takeshi Sugaya and Shin-ichirou Nishimatsu and Keiji Tanimoto and Eriko Takimoto and Toshio Yamagishi and Kouji Imamura and Shinji Goto and Kazunori Imaizumi and Yukimasa Hisada and Aiko Otsuka},
  journal={The Journal of biological chemistry},
  volume={270 32},
Angiotensin (AT) II, the bioactive octapeptide in the renin-angiotensin system that plays a key role in cardiovascular homeostasis, exerts its multiple effects through the different types of AT receptors, AT1a, AT1b, and AT2. Previously, we showed chronic hypotension in angiotensinogen (the precursor of AT)-deficient mice and a dramatic increase in renin mRNA levels in its kidney, but it remains unclear which types of AT receptors regulate the blood pressure and renin gene expression. In order… CONTINUE READING
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