Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction.

@article{Harada1999AngiotensinIT,
  title={Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction.},
  author={Koichiro Harada and Takeshi Sugaya and Kazuo Murakami and Yoshio Yazaki and Issei Komuro},
  journal={Circulation},
  year={1999},
  volume={100 20},
  pages={2093-9}
}
BACKGROUND Angiotensin II (Ang II) has been implicated in ventricular remodeling after myocardial infarction (MI), which is an important determinant for prognosis after MI. The aim of this study was to determine whether Ang II type 1A receptor (AT(1A))-mediated Ang II signals are critically involved in the mortality and LV remodeling after MI. METHODS AND RESULTS We examined survival, cardiac geometry and function, cardiac fibrosis, and gene expression of AT(1A) knockout (KO) mice and wild… CONTINUE READING

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