Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature.

Abstract

Angiotensin II type 1 (AT(1)) receptor signaling has been implicated in cerebral microvascular alterations associated with ischemia, diabetes mellitus, hypercholesterolemia, and atherosclerosis. Platelets, which express AT(1) receptors, also appear to contribute to the thrombogenic and inflammatory responses that are elicited by these pathological… (More)

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@article{Ishikawa2007AngiotensinIT, title={Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature.}, author={Mami Ishikawa and Eiichi Sekizuka and Noriyuki M. Yamaguchi and H. Nakadate and S. Terao and D. Neil Granger and Haruyuki Minamitani}, journal={American journal of physiology. Heart and circulatory physiology}, year={2007}, volume={292 5}, pages={H2306-15} }