Angiotensin II type 1 receptor-modulated signaling pathways in neurons

@article{Richards1999AngiotensinIT,
  title={Angiotensin II type 1 receptor-modulated signaling pathways in neurons},
  author={Elaine M. Richards and Mohan K. Raizada and Craig H. Gelband and Colin Sumners},
  journal={Molecular Neurobiology},
  year={1999},
  volume={19},
  pages={25-41}
}
Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasopressin, secretion, effects that involve the modulation of brain noradrenergic pathways. This review focuses on the intracellular events that mediate the functional effects of Ang… CONTINUE READING

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