Angiotensin II type 1-receptor mediated changes in heparan sulfate proteoglycans in human SV40 transformed podocytes.

@article{Brinkkoetter2004AngiotensinIT,
  title={Angiotensin II type 1-receptor mediated changes in heparan sulfate proteoglycans in human SV40 transformed podocytes.},
  author={Paul-Thomas Brinkkoetter and Simone Holtgrefe and Fokko Johannes van der Woude and Benito Antonio Yard},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 1},
  pages={33-40}
}
In patients with diabetic nephropathy, glomerular staining for heparan sulfate proteoglycans (HSPG) side chains and for agrin is decreased. In the present study, the influence of angiotensin II (AngII) on the production of HSPG in SV40 transformed podocytes was investigated. SV40 transformed human podocytes were cultivated with or without 1 microM AngII, and HSPG production was measured by sequential DEAE-anion exchange chromatography and HPLC-DEAE separation. Expression of agrin was studied by… CONTINUE READING

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