Angiotensin II type 1 receptor blockers.

  title={Angiotensin II type 1 receptor blockers.},
  author={Michel Burnier},
  volume={103 6},
Thereafter, the development of pharmacological probes that block the renin-angiotensin system helped define the contribution of this system to blood pressure control and to the pathogenesis of diseases such as hypertension, congestive heart failure, and chronic renal failure. Thus, the concept of treating hypertension and congestive heart failure by a specific blockade of the renin-angiotensin system was first established with the use of saralasin, a nonselective peptidic antagonist of… CONTINUE READING