Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.

@article{Shiuchi2004AngiotensinIT,
  title={Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.},
  author={Tetsuya Shiuchi and Masaru Iwai and Huan-Sheng Li and Lan Wu and Li-juan Min and Jian-Mei Li and Midori Okumura and T A Cui and Masatsugu Horiuchi},
  journal={Hypertension},
  year={2004},
  volume={43 5},
  pages={1003-10}
}
Angiotensin II has been shown to contribute to the pathogenesis of insulin resistance; however, the mechanism is not well understood. The present study was undertaken to investigate the potential effect of an angiotensin II type-1 (AT1) receptor blocker, valsartan, to improve insulin resistance and to explore the signaling basis of cross-talk of the AT1 receptor- and insulin-mediated signaling in type 2 diabetic KK-Ay mice. Treatment of KK-Ay mice with valsartan at a dose of 1 mg/kg per day… CONTINUE READING

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