Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

@article{Ongali2014AngiotensinIT,
  title={Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model},
  author={Brice Ongali and Nektaria Nicolakakis and Xin-Kang Tong and Tahar Aboulkassim and Edith Hamel},
  journal={Neurobiology of Disease},
  year={2014},
  volume={68},
  pages={126-136}
}
Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may protect from Alzheimer's disease (AD). We studied the ability of the AT1 receptor antagonist losartan to cure or prevent AD hallmarks in aged (~18months at endpoint, 3months treatment) or adult (~12months at endpoint, 10months treatment) human amyloid precursor protein (APP) transgenic mice. We tested learning and memory with the Morris water maze, and evaluated neurometabolic and neurovascular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Within the Brain: The Renin Angiotensin System

International journal of molecular sciences • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…