Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis

  title={Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis},
  author={A. Hirose and M. Ono and T. Saibara and Yasuko Nozaki and Kosei Masuda and Akemi Yoshioka and M. Takahashi and N. Akisawa and S. Iwasaki and J. Oben and S. Onishi},
  • A. Hirose, M. Ono, +8 authors S. Onishi
  • Published 2007
  • Medicine
  • Hepatology
  • Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma. At present there is no effective and accepted therapy for NASH. The renin‐angiotensin system is involved in hepatic fibrosis through activation of hepatic stellate cells, major fibrogenic cells in the liver. Hepatic stellate cells are activated by liver injury to express… CONTINUE READING
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