Angiotensin II type 1 receptor blockade with candesartan protects the porcine myocardium from reperfusion-induced injury.

@article{Shimizu1998AngiotensinIT,
  title={Angiotensin II type 1 receptor blockade with candesartan protects the porcine myocardium from reperfusion-induced injury.},
  author={Masafumi Shimizu and Qing-Dong Wang and P. O. Sj{\"o}quist and Lars Ryd{\'e}n},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={32 2},
  pages={231-8}
}
Angiotensin-converting enzyme (ACE) inhibitors reduce myocardial ischemia/reperfusion injury. It is unclear whether reduced formation of angiotensin II or attenuated degradation of bradykinin is responsible for the beneficial effects. We investigated the role of endogenous angiotensin II in ischemia/reperfusion injury by studying the effects of the angiotensin II type 1 receptor antagonist candesartan on myocardial function, infarct size, and perfusion after ischemia/reperfusion. Anesthetized… CONTINUE READING
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