Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.

@article{Kim1995AngiotensinIT,
  title={Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.},
  author={Shokei Kim and Masafumi Kawamura and Hideki Wanibuchi and Kouichi Ohta and A Hamaguchi and Takashi Omura and Tokihito Yukimura and Katsuyuki Miura and Hiroshi Iwao},
  journal={Circulation},
  year={1995},
  volume={92 1},
  pages={88-95}
}
BACKGROUND Vascular injury activates various kinds of genes, including proto-oncogenes, growth factors, and extracellular matrix proteins. However, the significance of activation of these genes in neointimal formation is poorly understood. Angiotensin II type 1 (AT1) receptor antagonist is shown to prevent neointimal formation after vascular injury, although the mechanism is unclear. To understand the molecular mechanism of vascular thickening, we examined the effects of AT1 receptor blockade… CONTINUE READING

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