Angiotensin II type 1 receptor blockade improves hyperglycemia-induced endothelial dysfunction and reduces proinflammatory cytokine release from leukocytes.

@article{Willemsen2007AngiotensinIT,
  title={Angiotensin II type 1 receptor blockade improves hyperglycemia-induced endothelial dysfunction and reduces proinflammatory cytokine release from leukocytes.},
  author={J. - Michael Bauschat Gunnar Duus Klaus - Uwe Hahn Wi Willemsen and Jan Westerink and Geesje M. Dallinga-Thie and Anton-Jan van Zonneveld and Carlo A. J. M. Gaillard and Ton J Rabelink and Eelco J P de Koning},
  journal={Journal of cardiovascular pharmacology},
  year={2007},
  volume={49 1},
  pages={6-12}
}
Angiotensin II and glucose share components of their intracellular redox signaling pathways in endothelial and inflammatory cells. We hypothesized that valsartan, an angiotensin II blocker, attenuates hyperglycemia-induced endothelial dysfunction and downregulates release of proinflammatory cytokines from leukocytes. A sustained hyperglycemic clamp (12 mmol/L) to induce endothelial dysfunction was performed in healthy volunteers before and after 4 weeks of treatment with 160 mg of valsartan… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…