Angiotensin II type 1 receptor antagonist protects ventricular and coronary endothelial function after 24-hour heart preservation.

BACKGROUND Angiotensin II type 1 (AT1) receptor antagonists may enhance the cyclic guanosine monophosphate-nitric oxide system and thereby attenuate ventricular and coronary endothelial dysfunction after heart preservation. METHODS We used an isolated rabbit heart preparation perfused with blood from a support rabbit. The rabbit heart was excised, stored… (More)