Angiotensin II type 1 receptor activation increases microvascular hydraulic permeability.

@article{Newton2004AngiotensinIT,
  title={Angiotensin II type 1 receptor activation increases microvascular hydraulic permeability.},
  author={Christopher R H Newton and Brian C Curran and Gregory P. Victorino},
  journal={Surgery},
  year={2004},
  volume={136 5},
  pages={1054-60}
}
BACKGROUND In addition to its vasoconstricting effects, angiotensin II (Ang II) has also demonstrated the ability to modulate microvessel permeability. We hypothesized that activation of the angiotensin II type 1 receptor (AT1) would increase hydraulic permeability. METHODS Hydraulic permeability (L(p)) was measured in rat mesenteric venules using the Landis micro-occlusion technique. Paired measures of L(p) were obtained at baseline and after perfusion with the AT1 agonist, [Sar(1… CONTINUE READING