Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species.

@article{Fliers2006AngiotensinIS,
  title={Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species.},
  author={Denis F{\'e}liers and Yves C. Gorin and Goutam Ghosh-Choudhury and Hanna Emily Abboud and Balakuntalam S Kasinath},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 4},
  pages={F927-36}
}
ANG II, a mediator of renal injury in diabetic renal disease, promotes vascular endothelial growth factor (VEGF) mRNA translation in proximal tubular epithelial (MCT) cells (Feliers D, Duraisamy S, Barnes JL, Ghosh-Choudhury G, and Kasimath BS. Am J Physiol Renal Physiol 288: F521-F529, 2005). The mechanism by which ANG II elicits this effect is not known. ANG II is known to induce oxidative stress and the rapidity of the effect suggested a role for reactive oxygen species (ROS). The aim of… CONTINUE READING
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