Angiotensin II stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes.

@article{Liu1998AngiotensinIS,
  title={Angiotensin II stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes.},
  author={Y Liu and Annarosa Leri and B Li and X Wang and W Cheng and J Kajstura and Piero Anversa},
  journal={Circulation research},
  year={1998},
  volume={82 11},
  pages={1145-59}
}
To determine whether angiotensin II (Ang II) stimulation of adult ventricular myocytes in vitro results in cellular hypertrophy, the changes in myocyte volume and protein content per cell were examined by confocal microscopy. Moreover, the possibility was considered that the upregulation of Ang II receptors on myocytes after infarction may potentiate and/or accelerate Ang II-mediated myocyte growth. Left ventricular myocytes isolated from control and failing hearts 3 days after infarction were… CONTINUE READING